Indications
By nephrologists only – for the prophylaxis of organ rejection patients receiving an allergenic kidney transplant.
Mechanism of action
Tacrolimus is an immunosuppressant. In organ transplant patients, it works by suppressing your body's immune response, helping your body to accept the new organ as if it were your own. In allergic eye disease, it works by decreasing the production of chemicals (eg. histamine) that cause allergic eye symptoms such as inflammation (redness and swelling).
Drug Interactions
When Tacrolimus capsule is prescribed with a given dose of a mycophenolic acid (MPA) product, exposure to MPA is higher with Tacrolimus co-administration than with cyclosporine co-administration with MPA, because cyclosporine interrupts the enterohepatic recirculation of MPA while tacrolimus does not. Monitor for MPA-associated adverse reactions and reduce the dose of concomitantly administered mycophenolic acid products as needed.
Side Effects
● Diarrhea
● Increased glucose level in blood
● Increased thirst
● Kidney damage
● Liver damage
● Nausea and vomiting
● Stomach pain
● Constipation
Precautions & Warning
Pregnancy: Not recommended
Breastfeeding: Not recommended as it can harm the fetus.
Dosage
As Directed by the Physician.
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